NEO PanTracer Pro

  • Next Generation Sequencing (NGS)
PanTracer Pro combines comprehensive genomic profiling of 500+ cancer-related genes with cancer type-directed ancillary testing, including IHC and HRD scoring, to provide personalized insights for therapy selection.
Turnaround time
10 Days

NGS: 8-10 Days
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
IHC: 2 Days

Level of Service

  • Global
New York Approved: No

Clinical Significance

PanTracer Pro incorporates a broad, next-generation sequencing panel for pan-solid tumor indications with cancer-type directed ancillary testing. The NGS assay detects single nucleotide variants (SNV), insertions/deletions (InDels), copy number variants (CNV), and RNA fusions and splice variants in a total of 517 genes (517 genes analyzed by DNA, 55 genes by RNA), plus microsatellite instability (MSI*) and tumor mutational burden (TMB). Specific cancer-type directed ancillary testing (IHC) includes therapy selection markers relevant to a patient's specific tumor type.

Specimen Requirements

NGS:
Preferred specimen (FFPE block): A formalin-fixed, paraffin-embedded (FFPE) tissue block is the preferred specimen type with >20% tumor and >5 mm2 of tissue surface area.
If submitting slides (instead of a block): Submit the following cut at 5-microns.
>25 mm2 of tissue: 10 unstained slides for samples with (2 sections per slide preferred)
10-24 mm2 of tissue: 20 unstained slides for samples (2 sections per slide preferred)

IHC:
Preferred specimen (FFPE block): A formalin-fixed, paraffin-embedded (FFPE) tissue block is the preferred specimen type. Do not use zinc fixatives.
If submitting slides (instead of a block): Submit the following cut at 4–5 microns. Please use positively-charged slides and 10% NBF fixative.
H&E slide: One (1) unbaked, unstained slide for H&E staining (required)
Cut Slides: Two to three (2–3) positively charged unstained slides for each IHC test/antibody ordered

Specimen Identification:
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

CPT Code(s)*

81459x1 for NGS 88342 x 1 or 88341 x 1; 88361 x 1; 88360 x 1 can be added for each IHC

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing
CNVs
MYCL1METPDGFRBRETCDK8PTEN
FGFR2MYCNERBB2AKT2ARATM
BRCA1BRCA2CCND1CCND3CCNE1CDK4
CDK6CHEK1CHEK2EGFRERBB3ERCC1
ERCC2ESR1FGF1FGF10FGF14FGF19
FGF2FGF23FGF3FGF4FGF5FGF6
FGF7FGF8FGF9FGFR1FGFR3FGFR4
JAK2KITKRASLAMP1ALKMDM2
MDM4NRASNRG1PDGFRAPIK3CAPIK3CB
BRAFMYCRAF1RICTORRPS6KB1TFRC
SNVs + Indels
ABL1ABL2CDKN2ACRLF2CSF1RFLT3
IKZF1IL7RJAK1JAK3NTRK1NTRK2
NTRK3PDGFRASH2B3TP53ASXL1BCOR
CEBPACSF3RDNMT3AETV6EZH2IDH1
IDH2HRASKMT2ANPM1PHF6PTPN11
RUNX1SETBP1SF3B1SRSF2STAG2TET2
U2AF1WT1ZRSR2BRIP1DDX41ERCC4
PALB2RAD51CSLX4TERCTERTXRCC2
AKT1ARID1AATRBARD1CDH1CDK12
CTNNB1ERBB4FANCAFANCCFANCD2FANCE
FANCFFANCGFANCLGATA3MLH1MRE11
MSH2MSH6NBNPMS2RAD50RAD51
RAD51BRAD51DRAD54LSMAD4SMOSRC
APCBAP1PBRM1BCL2BIRC3BTK
CARD11CD79BMYD88NOTCH1CXCR4EPCAM
FBXW7PLCG2MUTYHPOLD1POLERNF43
STK11ATRXACVR1BAKT3AMER1ARAF
ARFRP1ARID1BARID2AURKAAURKBAXIN1
AXLBCL2L1BCL2L2BCL6BCORL1BLM
BRD4BTG1EMSYCBFBCBLCCND2
CD274CD79ACDC73CDKN1ACDKN1BCDKN2B
CDKN2CCHD2CHD4CICCREBBPCRKL
CTCFCTNNA1CUL3CYLDDAXXDDR2
DICER1DOT1LEP300EPHA3EPHA5EPHA7
EPHB1ERGERRFI1TENT5CFASFAT1
FHFLCNFLT1FLT4FOXL2FOXP1
FRS2FUBP1GABRA6GATA1GATA2GATA4
GATA6GID4GLI1GNA11GNA13GNAQ
GNASADGRA2GRIN2AGRM3GSK3BHGF
H3C3HNF1AHSD3B1HSP90AA1IGF1RIGF2
IKBKEINHBAINPP4BIRF2IRF4IRS2
JUNKAT6AKDM5AKDM5CKDM6AKDR
KEAP1KELKLHL6LMO1LRP1BLYN
LZTR1MAGI2MAP2K1MAP2K2MAP2K4MAP3K1
MCL1MED12MEF2BMEN1MITFMPL
MTORNF1NF2NFE2L2NFKBIANKX2-1
NOTCH2NOTCH3NSD1NUP93PAK3PAX5
PDCD1LG2PIK3C2BPIK3CGPIK3R1PIK3R2PPP2R1A
PRDM1PREX2PRKAR1APRKCIPRKDCPRSS8
PTCH1QKIRAC1RANBP2RARARB1
RBM10ROS1RPTORRUNX1T1SDHASDHB
SDHCSDHDSETD2SLIT2SMAD2SMAD3
SMARCA4SMARCB1SNCAIPSOCS1SOX10SOX2
SOX9SPENSPOPSPTA1STAT3STAT4
SUFUSYKTAF1TBX3TGFBR2TNFAIP3
TNFRSF14TOP1TOP2ATSC1TSC2TSHR
VEGFAVHLCCN6XPO1ZBTB2ZNF217
ZNF703EEDH3-3ASUZ12ABRAXAS1GEN1
GREM1HOXB13ACVR1ALOX12BANKRD11ANKRD26
ARID5BASXL2AXIN2B2MBBC3BCL10
BCL2L11BCRBMPR1ACALRCASP8CD276
CD74CENPACOP1CSNK1A1CTLA4CUX1
DCUN1D1DHX15DIS3DNAJB1DNMT1DNMT3B
E2F3EGFL7EIF1AXEIF4A2EIF4EELOC
EML4ERCC3ERCC5ETS1ETV1ETV4
ETV5EWSR1FANCIFLI1FOXA1FOXO1
FYNGPS2H1-2H2BC5H3-3BH3-4
H3-5H3C1H3C10H3C11H3C12H3C13
H3C14H3C15H3C4H3C6H3C7H3C8
H3C2HNRNPKICOSLGID3IFNGR1IGF1
IL10INHAINPP4AINSRIRS1KIF5B
KLF4LATS1LATS2MALT1MAP3K13MAP3K14
MAP3K4MAPK1MAPK3MAXMDC1MGA
MSH3MST1MST1RMYBMYOD1NAB2
NCOA3NCOR1NEGR1NKX3-1NOTCH4NUTM1
PAK1PAK5PARP1PAX3PAX7PAX8
PDCD1PDPK1PGRPHOX2BPIK3C2GPIK3C3
PIK3CDPIK3R3PIM1PLK2PMAIP1PMS1
PNRC1PPARGPPM1DPPP2R2APPP6CPRKN
PTPRDPTPRSPTPRTRAB35RAD21RAD52
RASA1RECQL4RELRHEBRHOARIT1
RPS6KA4RPS6KB2RYBPSDHAF2SH2D1ASHQ1
SMARCD1SMC1ASMC3SOX17STAG1STAT5A
STAT5BSTK40TCF3TCF7L2TET1TFE3
TGFBR1TMEM127TMPRSS2TP63TRAF2TRAF7
VTCN1XIAPYAP1YES1ZBTB7AZFHX3
KMT2AT3
Genomic Signatures
MSITMB
RNA Sequencing
Fusions
ABL1CSF1RETV6FGFR1FLT3JAK2
KMT2ANTRK1NTRK2NTRK3PDGFRAPDGFRB
KMT2AT3ALKBRAFEML4EWSR1FGFR2
FGFR3RAF1ROS1FGFR4NOTCH1NOTCH2
NRG1RETBRCA1BRCA2CDK4MSH2
PIK3CAAKT3AXLERBB2ERGESR1
ETS1ETV1ETV4ETV5FLI1FLT1
KDRKIF5BKITMYCNOTCH3PAX3
PAX7PPARGRPS6KB1TMPRSS2
RNA Sequencing
AR-V7AR
EGFRvIIIMET exon 14 Skipping
EGFRMET

Last Updated: January 23, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.