The NeoTYPE Precision Profile analyzes 83 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions.
NGS (79 genes + MSI and TMB)
A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥20% for colorectal specimens or ≥40% with paired normal tissue available for non-colorectal specimens.
IHC (2 biomarkers)
* PD-L1 LDT (tech-only available)
* Pan-TRK
Reflex rule: If Pan-TRK IHC is expressed or equivocal, we will reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added.
NeoTYPE® Precision Profile for Solid Tumors
- Next Generation Sequencing (NGS)
Specimen Requirements
FFPE solid tumor tissue: Paraffin block is preferred. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81457x1, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
Turnaround time
14 Days
NGS: 14 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Level of Service
- Global
Integrations
Request electronic integrations →
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| AKT1 | ALK | APC | ARAF | ATM | ATR |
| BARD1 | BRAF | BRCA1 | BRCA2 | BRIP1 | CDH1 |
| CDK12 | CDKN2A | CHEK1 | CHEK2 | CSF1R | CTNNB1 |
| EGFR | ERBB2 | ERBB4 | ESR1 | FANCA | FANCC |
| FANCD2 | FANCE | FANCF | FANCG | FANCL | FBXW7 |
| FGFR1 | FGFR2 | FGFR3 | GNA11 | GNAQ | GNAS |
| HNF1A | HRAS | IDH1 | IDH2 | KDR | KIT |
| KRAS | MAP2K1 | MET | MLH1 | MRE11 | MSH2 |
| MSH6 | MTOR | NBN | NF1 | NOTCH1 | NRAS |
| PALB2 | PDGFRA | PIK3CA | PMS2 | PTCH1 | PTEN |
| PTPN11 | RAD50 | RAD51 | RAD51B | RAD51C | RAD51D |
| RAD54L | RB1 | RET | SMAD4 | SMARCB1 | SMO |
| SRC | STK11 | TERT | TP53 | TSC1 | TSC2 |
| VHL | |||||
| Genomic Signatures | |||||
|---|---|---|---|---|---|
| MSI | TMB | ||||
Immunohistochemistry (IHC)
| Expression | |||||
|---|---|---|---|---|---|
| NTRK1 | NTRK2 | NTRK3 | PD-L1 | ||
Last Updated: March 31, 2026