This panel is designed to detect key genetic alterations associated with lymphoma through next-generation sequencing (NGS) and fluorescence in situ hybridization (FISH).
DNA NGS SNV/Indel (13 biomarkers)
BCL2, BCL6, BRAF, CARD11, CCND1 (BCL1), CD79B, EZH2, MYD88, NOTCH1, NOTCH2, NRAS, TP53
FISH (2 biomarkers)
CCND1 (BCL1)/IgH t(11;14)
BCL2/IgH t(14;18)
Test Interpretation: Reports provide a summary interpretation of all results.
NeoTYPE® Lymphoma Profile
- Next Generation Sequencing (NGS)
Specimen Requirements
Bone Marrow Aspirate: 2 mL in EDTA tube.
Peripheral Blood: 5 mL in EDTA tube.
H&E slide: Required, plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use: Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Storage and Transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Please select Extract & Hold - TNA if specimen hold service is desired.
CPT Code(s)*
81450x1
88374x2 (automated analysis) or 88377x2 (manual analysis)
Turnaround time
14 Days
NGS: 14 Days
FISH: 5 Days
Level of Service
- Global
Integrations
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New York Approved: No
Clinical Significance
Genes analyzed in this profile have known roles in lymphoma pathogenesis. Testing is useful for diagnosis, classification, prognosis, and treatment decisions. It is also useful to distinguish between activated B-cell-like (ABC) and germinal center (GC) subtypes, especially in diffuse large B-cell lymphoma (DLBCL).
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| BCL2 | BCL6 | BRAF | CARD11 | CCND1 | CD79B |
| EZH2 | MYD88 | NOTCH1 | NOTCH2 | NRAS | TP53 |
Fluorescence In Situ Hybridization (FISH)
| Translocation(s) | |||||
|---|---|---|---|---|---|
| t(11;14) | t(14;18) | ||||
Last Updated: March 31, 2026