The Sarcoma Comprehensive NGS Fusion Panel is an RNA‑based next‑generation sequencing (NGS) assay designed to detect gene translocations and fusions, including those with known and novel fusion partners, associated with sarcoma.
NGS – RNA Fusions (97 genes)
This panel detects translocations and fusions involving a comprehensive set of sarcoma‑associated genes, including both known and novel fusion partners.
Legacy Test Information
As of May 12, 2025, the Sarcoma Comprehensive NGS Fusion Panel replaces the following tests, which are no longer offered:
* Ewing Sarcoma NGS Fusion Panel
* NeoTYPE® Liposarcoma Fusion Profile
* Non‑Ewing Sarcoma NGS Fusion Panel
* Rhabdomyosarcoma NGS Fusion Panel
Sarcoma Comprehensive NGS Fusion Panel
- Next Generation Sequencing (NGS)
- Epic Aura Integration
Specimen Requirements
FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81456
Turnaround time
21 days
Level of Service
- Global
Integrations
- Epic Aura
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
RNA Sequencing
| Fusions | |||||
|---|---|---|---|---|---|
| ACTB | AHRR | ALK | ASPSCR1 | ATF1 | ATIC |
| BCOR | BRAF | C11orf95 | CAMTA1 | CARS1 | CCNB3 |
| CDH11 | CIC | CLTC | CNBP | COL1A1 | COL1A2 |
| CREB1 | CREB3L1 | CREB3L2 | CSF1 | CTNNB1 | DDIT3 |
| DUX4 | EML4 | EPC1 | ERG | ETV1 | ETV4 |
| ETV6 | EWSR1 | FEV | FLI1 | FOXO1 | FRK |
| FUS | GLI1 | HAS2 | HEY1 | HMGA2 | IL2RB |
| ITK | JAZF1 | LMNA | LPP | MEAF6 | MRTFB |
| MYH9 | MYLK | NAB2 | NCOA1 | NCOA2 | NFATC2 |
| NFIB | NR4A3 | NTRK1 | NTRK2 | NTRK3 | NUTM2A |
| NUTM2B | OMD | PATZ1 | PAX3 | PAX7 | PBX1 |
| PDGFB | PDGFRB | PHF1 | PLAG1 | POU5F1 | RAD51B |
| RANBP2 | ROS1 | SEC31A | SRF | SS18 | SSX1 |
| SSX2 | SSX4B | STAT6 | SUZ12 | SYK | TAF15 |
| TCF12 | TEAD1 | TFE3 | TFG | THRAP3 | TPM3 |
| TPM4 | USP6 | WT1 | WWTR1 | YAP1 | YWHAE |
| ZNF444 | |||||
Last Updated: March 31, 2026