This test includes probes for genetic abnormalities commonly associated with plasma cell myeloma and multiple myeloma. The following genetic markers are tested:
1p-, 1q+, iso(1q): CDKN2C (1p32), CKS1B (1q21)
FGFR3/IgH t(4;14)
CCND1/IgH t(11;14)
13q- (13q14, 13q34)
IgH/MAF t(14;16)
IgH/MAFB t(14;20)
17p- (TP53 17p13.1, NF1 17q11.2)
Test Customization: Probes may be ordered separately.
Plasma Cell Myeloma Prognostic FISH Panel
- FISH
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 7 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
Note for plasma cell enrichment: Will be performed on bone marrow samples unless otherwise directed by the client. Plasma cell enrichment was not validated using peripheral blood; therefore, it is not recommended as a screening specimen unless increased plasma cells are seen on blood smear. Specimens should be received in our laboratory within 72 hours of collection.
Storage and Transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Specimens should be received in our laboratory within 72 hours of collection. NYS clients please provide date and time of collection.
CPT Code(s)*
Automated Analysis: 88374x7.
Manual Analysis: 88377x7.
Turnaround time
3-5 Days
Level of Service
- Global
- Tech Only
Integrations
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New York Approved: Yes
Clinical Significance
This panel may be useful for prognostic purposes. It has predominantly non-favorable prognostic markers with the exception of t(11;14) which is generally considered to be a standard risk and may help guide therapy.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
Fluorescence In Situ Hybridization (FISH)
| Translocation(s) | |||||
|---|---|---|---|---|---|
| CCND1(BCL1)/IgH t(11;14) | FGFR3/IgH t(4;14) | ||||
| MAF/IgH t(14;16) | MAFB/IgH t(14;20) | ||||
| Deletion(s) | |||||
|---|---|---|---|---|---|
| 13q | 1p | TP53 | |||
| Aneuploidy | |||||
|---|---|---|---|---|---|
| 1p-, 1q+, iso(1q) | |||||
Last Updated: March 06, 2026