NeoSITE Melanoma is a second-generation FISH assay that aids diagnostic discrimination between nevi and melanoma by informing of chromosomal gains or losses in four regions predictive of malignancy.
FISH (5 biomarkers):
RREB1 (6p25)
MYC (8q24)
CDKN2A p16 (9p21)
Centromere 9
CCND1 (11q13)
Clinical Indication:
* Melanoma
NeoSITE™ Melanoma
- FISH
Specimen Requirements
Paraffin Block: Send block. For tech-only testing, include H&E slide with target area circled (required).
Cut Slides: Slides should be cut at 4 micron thickness. For global testing, send 5 unstained slides. For tech-only, send 4-5 unstained slides plus H&E slide with target area circled (required).
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88377x2 manual or 88374x2 automated
Turnaround time
3-5 Days
Level of Service
- Global
- Tech Only
Integrations
Request electronic integrations →
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
Fluorescence In Situ Hybridization (FISH)
| Aneuploidy | |||||
|---|---|---|---|---|---|
| CCND1 | Centromere 9 | ||||
| MYC | RREB1 | ||||
Last Updated: March 31, 2026