HER2 (Human Epidermal Growth Factor Receptor 2 / ERBB2) — FISH
FISH Probes:
HER2 / ERBB2 (17q11.2–q12) | Chromosome 17 (CEN17)
Clinical Indication: Breast cancer
Method:
Dual‑color fluorescence in situ hybridization (FISH) to assess ERBB2 (HER2) gene copy number relative to chromosome 17
HER2 Breast Cancer
- FISH
Specimen Requirements
Pathology Report: A copy of the pathology report is required for HER2 testing (global cases only).
Bone Marrow Aspirate: N/A
Peripheral Blood: N/A
Fresh, Unfixed Tissue: N/A
Fluids: N/A
Paraffin block: Send paraffin block. Also send circled H&E slide for tech-only (required).
Cut slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Storage and Transportation
For global HER2 FISH cases we require a copy of the HER2 IHC pathology report. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x1 automated. Codes may differ if manual analysis is performed.
Turnaround time
3-5 Days
Level of Service
- Global
- Tech Only
Integrations
Request electronic integrations →
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
Fluorescence In Situ Hybridization (FISH)
| Amplification(s) | |||||
|---|---|---|---|---|---|
| ERBB2 | |||||
Last Updated: April 03, 2026