Ploidy FISH (Centromeres 1 and 11) with p57 IHC.
Ploidy FISH analyzes chromosomal centromeres 1 and 11 to assess ploidy status, aiding in the distinction between triploidy (commonly associated with partial mole) and diploidy (commonly associated with complete mole).
FISH Probes (2 biomarkers)
* Centromere 1 (1p11.1–q11.1)
* Centromere 11 (11q12)
Associated IHC Antibody Marker (1 biomarker)
p57
Clinical Indications
* Complete molar pregnancy
* Partial molar pregnancy
* Abortus with hydropic changes
Service level
This test is available on a consult basis only.
Ploidy FISH for Molar Pregnancy
- FISH
Specimen Requirements
Bone Marrow Aspirate: N/A
Peripheral Blood: N/A
Fresh, Unfixed Tissue: N/A
Paraffin Block: H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns.
Note: Specimen must contain villi and/or fetal tissue.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88377x1 manual or 88374x1 automated
Turnaround time
3-5 Days
Level of Service
- Global
Integrations
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New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
Fluorescence In Situ Hybridization (FISH)
| Polyploidy | |||||
|---|---|---|---|---|---|
| Centromere 1 | Centromere 11 | ||||
Last Updated: March 31, 2026